Micrin research
Micrin time-lapse video
Micrin is a ‘health housekeeping’ hormone involved in regulating development, bodily maintenance, reproduction and senescence. Corroborated pioneering research has shown that micrin can significantly reduce tissue overgrowth affecting the heart, liver, kidneys and other visceral and endocrine organs, and retard tumour cell growth. The intention is to exploit micrin-related drug candidates in areas of unmet medical need such as infertility, cardiac hypertrophy, polycystic kidney disease, and benign and malignant proliferative diseases of the prostate and breast.
Micrin preferentially targets abnormal cells. Breast tumour cells in culture are shown in the time-lapse movie. Exposed to a low dose of micrin, the cells look like they are exploding and disappearing. In fact they are committing suicide, a process known as apoptosis.
First there is cellular shrinkage, then chromatin condensation, DNA fragmentation and other intracellular changes that look like density changes. Membrane blebbing follows and ‘apoptotic body’ formation (sealing off of cytoplasm into small discrete units). Surrounding cells engulf the apoptotic bodies, by phagocytosis, before themselves succumbing to micrin.